Advance research on association between environmental compound and parkinson's disease
10.3760/cma.j.issn.0253-9624.2016.10.018
- VernacularTitle:环境化合物与帕金森病的研究进展
- Author:
Xiangting LI
1
;
Dingfang CAI
Author Information
1. 200032上海，复旦大学附属中山医院中西医结合科，中西医结合研究所神经病学实验室
- Keywords:
Parkinson disease;
Risk factors;
Environmental compound
- From:
Chinese Journal of Preventive Medicine
2016;50(10):922-926
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease (PD) was the second most common neurodegenerative disorder after Alzheimer's disease. Incidence of PD was ascending year by year. The etiology of PD is poorly understood, involving aging, genetic and environmental factors. Recently, environmental compound had attracted more and more research interest. Studies and extrapolation from epidemiology, animal experiments and cell culture suggested that environmental compound had involved in the molecular mechanisms including mitochondrial dysfunction, oxidative stress, microglia activation,abnormal aggregation of α-synuclein and autophagy damage,which seemed to increase PD risk.
