Research progress on GSDME-mediated cell pyroptosis resulting in GSDME type hearing loss

VernacularTitle:GSDME介导的细胞焦亡致GSDME型耳聋的研究进展
Author: Liting PENG ¹ ; Xi WANG ; Weiqian WANG ; Jincao XU ; Xue GAO
Author Information

1. 锦州医科大学火箭军特色医学中心研究生培养基地，北京　100088
Keywords: GSDME-related hearing loss; GSDME gene; Pyroptosis
From: Chinese Journal of Medical Genetics 2024;41(10):1271-1276
CountryChina
Language:Chinese
Abstract: Pyroptosis is a novel mode for programmed cell death discovered and confirmed in recent years. The Gasdermins (GSDMs) family is a key effector molecule mediating pyroptosis. As an important cause of extensive inflammatory damage and side effects of conventional chemotherapy drugs, anomalous pyroptosis has also been associated with hearing loss, tumor, and disorders of the immune system. The GSDME protein, encoded by the GSDME ( DFNA5) gene, belongs to the GSDMs family and is a key factor mediating pyroptosis. Gain-of-function variants of the GSDME gene can lead to GSDME-related hearing loss, which shows an autosomal dominant inheritance. This article has reviewed the role of GSDME-mediated pyroptosis in the pathogenesis of GSDME-related hearing loss, with an aim to provide insights into the treatment of GSDME-related hearing loss.