Morphological Features of Metastatic Gastrointestinal Stromal Tumors after Gleevec Treatment: Two Cases Report.
- Author:
Joon Hyuk CHOI
1
;
Young Kyung BAE
;
Sun Kyo SONG
;
Hong Jin KIM
;
Min Chul SHIM
;
Kyung Hee LEE
Author Information
1. Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea. joonhyukchoi@ynu.ac.kr
- Publication Type:Case Report
- Keywords:
Gastrointestinal stromal tumor;
Gleevec;
Liver;
Metastasis;
Morphology
- MeSH:
Benzamides;
Female;
Fibrosis;
Gastrointestinal Stromal Tumors;
Hemorrhage;
Humans;
Hyalin;
Liver;
Middle Aged;
Necrosis;
Neoplasm Metastasis;
Piperazines;
Prognosis;
Pyrimidines;
Imatinib Mesylate
- From:Korean Journal of Pathology
2009;43(4):368-373
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report two patients with metastatic gastrointestinal stromal tumors (GISTs) with a focus on the morphological features related to Gleevec treatment. In case 1, a 50-year-old woman presented with a 1.8 cm metastatic GIST in the liver after resection of a gastric GIST. Majority of the metastatic tumor showed fibrosis and hyalinization after 8 weeks of Gleevec treatment. CD117-positive cells were present in approximately 1% of the overall tumor. In case 2, a 2 cm and 14 cm metastatic liver masses were found in a 54-year-old man who had a rectal GIST. After 4 weeks of Gleevec treatment, metastatic tumors showed a decrease in size on CT scan. The metastatic tumors showed a decrease in number of tumor cells. The hemorrhage, cystic changes, necrosis, and fibrosis made up approximately 90% of the tumor. The morphological features related to Gleevec treatment are important for correct diagnosis and evaluation of tumor response and prognosis.
