Neurofilament light chain and Polyglutamine disease
10.3760/cma.j.cn511374-20240116-00049
- VernacularTitle:神经丝轻链蛋白与多聚谷氨酰胺病
- Author:
Xiafei LONG
1
;
Zhao CHEN
;
Hong JIANG
Author Information
1. 中南大学湘雅医院神经内科，长沙 410008
- Keywords:
Polyglutamine disease;
Huntington disease;
Spinocerebellar ataxia;
Neurofilament light chain;
Biomarker
- From:
Chinese Journal of Medical Genetics
2024;41(9):1131-1138
- CountryChina
- Language:Chinese
-
Abstract:
Polyglutamine (polyQ) disease is a group of hereditary neurodegenerative diseases. It has become clear that brain damage may occur decades before the onset of symptoms. As a sensitive marker for neuro-axonal damages, neurofilament light chain (NfL) has appeared as a promising biomarker for neurological diseases. it may be used as a preclinical and clinical marker for the neurodegeneration in polyQ diseases, and is closely correlated with disease severity and progression, in particular different disease stages. This article has provided a review for the value of NfL as a biomarker in polyQ disease and its future research directions.
