CACNA1C rs58619945 genotype influences the cortical thickness of attention network among patients with Bipolar Ⅰ disorder
10.3760/cma.j.cn511374-20230803-00035
- VernacularTitle:CACNA1C rs58619945基因型对双相情感障碍Ⅰ型患者注意网络皮质厚度的影响
- Author:
Xiaofei ZHANG
1
;
Xiaoyu LIANG
;
Xiaofang CHENG
;
Jianshan CHEN
;
Wenhao DENG
;
Yizhi ZHANG
;
Liqian CUI
;
Xiongchao CHENG
;
Xuan LI
;
Chanjuan YANG
;
Biyu YE
;
Liping CAO
Author Information
1. 广州医科大学附属脑科医院儿少科，广州 510370
- Keywords:
Bipolar disorder;
Attention network;
Imaging genetics;
Cortical thickness;
CACNA1C rs58619945
- From:
Chinese Journal of Medical Genetics
2024;41(9):1045-1052
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the impact of CACNA1C rs58619945 genotype on the cortical thickness of attentional networks in patients with Bipolar 1 disorder type (BD-Ⅰ). Methods:From August 2013 and August 2019, a total of 155 BD-Ⅰ patients were recruited from the outpatient and inpatient Departments of the Affiliated Brain Hospital of Guangzhou Medical University, along with 82 healthy controls (HC) from the community and university. Genotype for the CACNA1C rs58619945 locus was determined for all BD-I patients and HC subjects, followed by 3.0 T magnetic resonance imaging scans to measure the cortical thickness in the alert, orienting, and executive control subnetworks. General linear models (GLMs) were used to evaluate the impact of CACNA1C rs58619945 on the cortical thickness of attentional networks. Concurrently, attentional dimension functions were assessed using repeatable battery for the assessment of neuropsychological status (RBANS) and Cambridge neuropsychological test automated battery rapid visual information processing (CANTAB RVP) test. This study was approved by the Medical Ethics Committee of the Affiliated Brain Hospital of Guangzhou Medical University(Ethics No. 2023-056). Results:Compared with the HC group, the BD-Ⅰ patients had shown reduced thickness in bilateral prefrontal cortex, bilateral posterior cingulate cortex, and bilateral superior temporal cortex( P<0.05). A significant interaction between the CACNA1C genotype and the cortical thickness(HC vs.BD) of right prefrontal cortex, right posterior parietal cortex and right superior temporal cortex was noted( P<0.05). Partial correlation analysis has demonstrated a significant correlation between CANTAB RVP and RBANS attention indices and cortical thickness in the right prefrontal cortex, right posterior cingulate cortex( P<0.05), and right superior temporal cortex predominantly among carriers of the BD-Ⅰ G allele. Conclusion:The G allele of CACNA1C rs58619945 is associated with cortical thickness of the right prefrontal cortex, right posterior cingulate cortex, and right superior temporal cortex in BD-Ⅰ, which are part of the alerting and orienting network.
