Population genomic researches of Escherichia coli
10.3760/cma.j.issn.0253-9624.2016.06.017
- VernacularTitle:大肠埃希菌的群体基因组学研究
- Author:
Yarong WU
1
;
Ruifu YANG
;
Yujun CUI
Author Information
1. 军事医学科学院微生物流行病研究所病原微生物生物安全国家重点实验室
- Keywords:
Escherichia coli;
Genome;
Genetics,population;
Population structure;
Epidemiology
- From:
Chinese Journal of Preventive Medicine
2016;50(6):554-558
- CountryChina
- Language:Chinese
-
Abstract:
Population genomics, an interdiscipline of genomics and population genetics, is booming in recent years with the rapid growth number of deciphered genomes and revolutionizes the understanding of bacterial population diversity and evolution dynamics. It also largely improves the prevention and control of infectious disease through providing more accurate genotyping and source-tracing results and more comprehensive characteristics of emerging pathogens. In this review, taking one of the best characterized bacteria, Escherichia coli, as model, we reviewed the phylogenetic relationship across its five major populations (designated A, B1, B2, D and E); and summarized researches on molecular mutation rate, selection signals, and patterns of adaptive evolution. We also described the application of population genomics in responding against large-scale outbreaks of E. coli O157:H7 and E. coli O104:H4. These results indicated that, although being a novel discipline, population genomics has played an important role in deciphering bacterial population structures, exploring evolutionary patterns and combating emerging infectious diseases.
