Progress of research on circular RNA encoding proteins in disease
10.3760/cma.j.cn511374-20230512-00280
- VernacularTitle:环状RNA编码蛋白在疾病发生机制中的作用研究进展
- Author:
Jiao JIAO
1
;
Dandan XU
;
Yan KONG
;
Zhijun ZHANG
Author Information
1. 东南大学医学院，南京 210009
- Keywords:
Circular RNA;
Translated protein;
Disease
- From:
Chinese Journal of Medical Genetics
2024;41(7):872-880
- CountryChina
- Language:Chinese
-
Abstract:
With the advance of research, non-coding RNA has been found to surpass the traditional definition to directly code functional proteins by coding sequence elements and binding with ribosomes. Among the non-coding RNAs, the function of circRNA encoded proteins has been most extensively studied. This study has used "circRNA", "encoded", and "translation" as the key words to search the PubMed and Web of Science databases. The retrieved literature was screened and traced, with the translation mechanism, related research methods, and correlation with diseases of circRNA reviewed. CircRNA can translate proteins through a non-cap-dependent pathway. Multiple molecular techniques, in particular mass spectrometry analysis, have important value in identifying unique peptide segments of circRNA encoded proteins for confirming their existence. The proteins encoded by the circRNA are involved in the pathogenesis of diseases of the digestive, neurological, urinary systems and the breast, and have the potential to serve as novel targets for disease diagnosis and treatment. This article has provided a comprehensive review for the basic theory, experimental methods, and disease-related research in the field of circRNA translation, which may provide clues for the identification of new diagnostic and therapeutic targets.
