Association of the -c.108C>T and c. 192Q>R polymorphisms of the PON1 gene with preeclampsia among Chinese women
10.3760/cma.j.cn511374-20230515-00287
- VernacularTitle:PON1基因-c.108C>T和c.192Q>R变异与子痫前期发病的相关性分析
- Author:
Xinyuan ZHANG
1
;
Ping FAN
;
Qingqing LIU
;
Xinghui LIU
;
Huai BAI
;
Yujie WU
;
Suiyan LI
Author Information
1. 西南交通大学生命科学与工程学院，成都 610031
- Keywords:
Preeclampsia;
Paraoxonase 1;
Genetic polymorphism;
Oxidative stress;
Lipid metabolism
- From:
Chinese Journal of Medical Genetics
2024;41(7):866-871
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the association of -c.108C>T and c. 192Q>R polymorphisms of paraoxonase 1 ( PON1) gene with preeclampsia (PE) and the influence of genotypes on the metabolic and oxidative stress indexes among Chinese women. Methods:This case-control study has included 334 patients with PE and 1337 healthy pregnant women. The -c.108C>T and c. 192Q>R genotypes were determined by PCR and restriction fragment length polymorphism method. Metabolic and oxidative stress parameters were also analyzed.Results:No statistical difference in the genotypic and allelic frequencies for the -c.108C>T and c. 192Q>R polymorphisms of the PON1 gene was found between the PE patients and the healthy controls ( P>0.05). Nevertheless, the 192Q-108T haplotype of these polymorphisms was associated with an increased risk of PE ( P = 0.007). Total antioxidant capacity(TAC)and atherosderosis index were higher in patients with the -108TT genotype compared with those with a CT genotype ( P < 0.05); whilst total oxidant status was lower in patients with a CT genotype compared with those with a CC genotype ( P = 0.036). Malondialdehyde level was higher in patients with a 192RR genotype compared with those with a QQ genotype ( P = 0.019). TAC level was higher in patients with a RR genotype compared with those with a QR genotype ( P = 0.015). Conclusion:The 192Q-108T haplotype of the PON1 gene is associated with the risk for PE. These polymorphisms may be associated with abnormal lipid metabolism and oxidative stress among Chinese PE patients.
