Progressive myoclonic epilepsy: a retrospective study of newly-diagnosed adult patients from a single center
10.3760/cma.j.cn511374-20230214-00073
- VernacularTitle:进行性肌阵挛癫痫：来自成人神经科患者的单中心回顾性分析
- Author:
Jianfang ZHANG
1
;
Jiajia ZHOU
;
Caihong JI
;
Dengchang WU
;
Kang WANG
Author Information
1. 浙江大学医学院附属第一医院神经内科，杭州 310009
- Keywords:
Epilepsy;
Myoclonus;
Phenotype;
Progressive myoclonus epilepsy;
Adult
- From:
Chinese Journal of Medical Genetics
2024;41(4):432-436
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To retrospectively analyze the clinical phenotype and pathogenic variants in patients with Progressive myoclonus epilepsy (PME).Methods:Clinical data and results of genetic testing for 11 patients diagnosed with PME at the Department of Neurology, the First Affiliated Hospital of Zhejiang University School of Medicine from June 2017 to December 2022 were collected and analyzed.Results:All of the patients, including 4 males and 7 females, had predominant action myoclonus. Three patients had myoclonus as the initial manifestation, whilst eight were diagnosed through genetic testing, including three cases with NEU1 gene variants, two with EPM2A gene variants (1 was novel), one with MT- TK gene variant, one with ATN1 gene variant, and one with CSTB gene variant. No pathogenic variant was identified in the remaining three cases. Among the eight patients with a genetic diagnosis, three were diagnosed with sialidosis, two with Lafora disease, one with Dentatorubral-pallidoluysian atrophy (DRPLA), one with Unverricht-Lundborg disease (ULD), and one with Myoclonic epilepsy with ragging red fibers (MERRF). Conclusion:Compared with pediatric patients, adult patients with PME represent a distinct subtype with slower progression and milder cognitive impairment.
