Association between oral hygiene, chronic diseases, and oral squamous cell carcinoma
10.3760/cma.j.issn.0253-9624.2015.08.005
- VernacularTitle:口腔卫生状况及慢性病与口腔鳞状细胞癌的关系研究
- Author:
Jiangfeng HUANG
1
;
Baochang HE
;
Fa CHEN
;
Fangping LIU
;
Lingjun YAN
;
Zhijian HU
;
Lisong LIN
;
Fei HE
;
Lin CAI
Author Information
1. 福建医科大学公共卫生学院流行病与卫生统计学系
- Keywords:
Oral sprays;
Oral hygiene;
Chronic diseases;
Case-control studies
- From:
Chinese Journal of Preventive Medicine
2015;(8):688-692
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between oral hygiene, chronic diseases, and oral squamous cell carcinoma. Methods We performed a case-control study with 414 cases and 870 controls in Fujian during September 2010 to January 2015. Patients were newly diagnosed oral squamous cell carcinoma cases according to the pathologic diagnoses, control subjects were enrolled from community population. Epidemiological data were collected by in-person interviews using a standard questionnaire . The contents of the questionnaire included demography character, history of tobacco smoking and alcohol drinking, dietary habits, oral hygiene status, family history of cancer, etc. Using unconditional logistic regression analysis to estimate adjusted odds ratios (OR) and corresponding 95% confidence intervals (CI) for oral hygiene and chronic diseases. We also stratified by sex, smoking and drinking to explore possible difference in association between subgroups. Results The multivariate logistic regression analysis indicated that number of teeth(20-27 and<20), bad prosthesis, recurrent oral ulceration were the risk factors of oral squamous cell carcinoma, the adjusted OR(95%CI) values were 2.01(1.49-2.73), 3.51(2.39-5.15), 2.33(1.79-3.04), 3.96(2.11-7.44), respectively;brushing tooth once per bay,brushing tooth more than once per day, regular oral health examination at least 5 years per time were the protective factors of oral squamous cell carcinoma, the adjusted OR(95%CI) values were 0.24 (0.13-0.43),0.13 (0.07-0.24), 0.37 (0.26-0.53), respectively. The stratification analysis indicated that recurrent oral ulceration could increase the risk of oral squamous cell carcinoma for non-smokers and non-drinking, the adjusted OR(95%CI) value was 5.21(2.42-11.18) and 4.71(2.37-9.36);and a risky effect of hypertension on risk of oral squamous cell carcinoma was observed for non-smokers and non-drinking, the adjusted OR(95%CI) values were 1.70 (1.10-2.61) and 1.58 (1.07-2.34) . Conclusions Oral hygiene and chronic diseases could affect the incidence of oral squamous cell carcinoma.
