Relationship between environmental tobacco smoke and lung cancer risk among nonsmokers in China：A meta-analysis
10.3760/cma.j.issn.0253-9624.2015.07.013
- VernacularTitle:中国非吸烟人群环境烟草烟雾暴露与肺癌发生关联的Meta分析
- Author:
Xin FU
1
;
Tienan FENG
;
Minfang WU
;
Ludan ZHANG
;
Chenghua JIANG
Author Information
1. 同济大学附属东方医院灾难医学系
- Keywords:
Lung neoplasms;
Meta-analysis;
Environmental tobacco smoke
- From:
Chinese Journal of Preventive Medicine
2015;(7):644-648
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the environmental tobacco smoke (ETS) and lung cancer by Meta-analysis. Methods We used“lung cancer/lung neoplasm”,“non-smoking/non-smoker”,“China/Chinese”,“case-control/case control”,“risk factor”,“environmental tobacco smoke/passive smoking”as key words, to search papers in databases including Chinese BioMedical Literature (CBM), China National Knowledge Internet (CNKI), Wanfang, Vip Citation Databases (VIP), PubMed and Web of Science databases, and collected the case-control studies on ETS and lung cancer among Chinese non-smokers from January 1999 to December 2013. A total of 129 research papers were collected. RevMan 5.2 software was used to calculate combined odds radio (OR) and 95%CI. Results Qualified 18 literatures were included, total cases 6 145 and controls 8 132. Consolidated results showed that ETS exposure could increase the risk of lung cancer, combined OR(95%CI)=1.52(1.42-1.64). Stratified analysis showed that ETS exposure was found to be significantly associated with an increasing risk of the lung cancer on non-smoking women and men, and combined OR(95%CI) were 1.58(1.42-1.75) and 1.34(1.08-1.65), respectively; the ETS exposure from family or the working environment could increase the risk of lung cancer, and combined OR(95%CI) were 1.48(1.20-1.82) and 1.38(1.13-1.69) respectively;childhood exposure and adult exposure were no significant statistical significance, and combined OR(95%CI) were 1.37(0.98-1.91), and 1.34(0.97-1.85) respectively. Conclusion Environmental tobacco smoke exposure was a significant risk factor of lung cancer among non-smokers in China.
