Association between ambient air pollution and stroke mortality in Wuhan, China：A time-series analysis
10.3760/cma.j.issn.0253-9624.2015.07.006
- VernacularTitle:武汉市江岸区大气污染与脑卒中死亡关系的时间序列分析
- Author:
Yunquan ZHANG
1
;
Kai WU
;
Cihua ZHU
;
Renjie FENG
;
Cunlu LI
;
Lu MA
Author Information
1. 430071武汉大学公共卫生学院流行病与卫生统计学系
- Keywords:
Air pollution;
Stroke;
Mortality;
Time-series analysis
- From:
Chinese Journal of Preventive Medicine
2015;(7):605-610
- CountryChina
- Language:Chinese
-
Abstract:
Objective Using time?series analyses to determine the association between ambient air pollution and stroke mortality in Jiang'an District of Wuhan, China from 2003 to 2010.Methods Data on daily stroke mortality for the period 2003 January 1 to 2010 December 31 was obtained from Jiang'an District Center for Disease Control and Prevention, Wuhan and data on relevant air pollution and meteorological factors from the local municipal environmental monitoring center and meteorology bureau of Wuhan, respectively. Application of a time-series analysis in generalized additive model was applied to evaluate the association between air pollution and stroke mortality. Results Annual average concentrations of PM10, SO2 and NO2 during the study period were (115.0 ± 60.0), (50.2 ± 33.7), and (57.6 ± 25.3)μg/m3, respectively. The total stroke death was 9 204, including 4 495 women, and 7 628 people aged over 65?years old. In single?pollutant model, a 10μg/m3 increase in previous day (lag 1 d) ambient pollutants was associated with 0.67%(95%CI:0.25%-1.10%) excess risk in stroke mortality for PM10, 0.87%(95%CI:0.13%-1.63%) excess risk for SO2 and 2.07% (95%CI: 1.08%-3.07%) excess risk for NO2, respectively. When co-pollutants were involved into the models, only NO2 remained strongly associated with stroke mortality(β=2.07,95%CI:1.08-3.07, P<0.001). A 10μg/m3 increase of NO2 in lag 1 d was associated with 1.77%(95%CI:0.54%-3.01%), 2.27%(95%CI:0.98%-3.57%) and 2.00%(95%CI:0.59%-3.43%) excess risk in stroke mortality, respectively, after adjusting for PM10, SO2, both PM10 and SO2. Age?specific and gender?specific analyses showed that the association between ambient air pollution and stroke mortality was stronger in the elderly (≥65 years old) people and women. A 10μg/m3 increase of PM10, SO2 and NO2 in lag 1 d was associated with excess stroke mortality of 0.97%(95%CI:0.37%-1.57%), 1.73%(95%CI:0.69%-2.78%) and 2.98% (95%CI:1.59%-4.39%) for women, respectively and 0.94%(95%CI:0.47%-1.42%), 1.06%(95%CI: 0.23%-1.90%) and 2.50%(95%CI:1.40%-3.62%) for the elderly people (>65 years old), respectively. Conclusion PM10 and gaseous pollutants (SO2, NO2) were significant risk factors for acute stroke death, and people aged over 65?years old and women were more susceptible to the effect of ambient pollutants on stroke mortality.
