Genetic analysis of a case with Adult-onset globoid cell leukodystrophy
10.3760/cma.j.cn511374-20221012-00683
- VernacularTitle:成年起病的球形细胞脑白质营养不良1例患者的遗传学分析
- Author:
Wenwen LIANG
1
;
Zhou ZHU
;
Yongkang FANG
Author Information
1. 华中科技大学同济医学院附属同济医院神经内科，武汉 430030
- Keywords:
Krabbe disease;
Galactocerebrosidase;
Symmetrical corticospinal tract lesion;
Compound heterozygous variants
- From:
Chinese Journal of Medical Genetics
2024;41(2):215-220
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical features and genetic etiology of a patient with adult-onset globoid cell leukodystrophy/Krabbe disease (KD).Methods:A patient who was admitted to the Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology on February 15, 2022 due to exacerbation of right leg weakness for over 4 years was selected as the study subject. Clinical data and results of medical imaging and genetic analysis were analyzed. Candidate variants were verified by family analysis.Results:The patient, a 36-year-old woman, had spasmodic gait as the primary presentation. Cranial magnetic resonance imaging (MRI) revealed symmetrical abnormalities in the bilateral corticospinal tracts, and the activity of β-galactocerebrosidase (GALC) in her white blood cells was significantly decreased. The patient was found to harbor compound heterozygous variants of the GALC gene, namely c.461C>A (p.Pro154His) and c. 1901T>C (p.Leu634Ser). Her mother, sister and nephew were heterozygous carriers of the c. 461C>A (p.Pro154His) variant, whilst her father was heterozygous for the c.1901T>C (p.Leu634Ser) variant. Conclusion:The patient was ultimately diagnosed with adult-onset KD, for which the compound heterozygous variants of the GALC gene may be accountable.
