Case-control studies of the relevant factors among Ningxia Hui and Han prostate cancer groups
10.3760/cma.j.issn.0253-9624.2014.12.013
- VernacularTitle:宁夏回族自治区的回族及汉族前列腺癌患病因素的病例对照研究
- Author:
Jiazhao LIU
1
;
Zhiqiang CHEN
;
Ruting BO
;
Ying DONG
;
Peng LI
;
Wenjun YANG
Author Information
1. 宁夏医科大学总医院
- Keywords:
Prostate neoplasms;
Minority groups;
Han population;
Case-control studies
- From:
Chinese Journal of Preventive Medicine
2014;(12):1083-1087
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the relevant factors and prostate cancer among Hui and Han populations.Methods The study involved 267 prostate cancer patients as cases ( 214 cases from Han population and 53 cases from Hui population ) and 534 prostatic hyperplasia patients as controls ( 428 cases from Han population and 106 cases from Hui population ) . All the patients were collected from the General Hospital of Ningxia Medical University during January of 2007 to September of 2013.The level of fasting blood glucose ( FBG) , total cholesterol ( TC) , triglyceride ( TG) , total prostate specific antigen (T-PSA), free prostate specific antigen (F-PSA) and free/total prostate specific antigen(F/T-PSA) were collected from the clinical medical records of the patients.Data were analyzed by the conditional logistic regression method, and attributable risk proportion ( ARP ) was calculated.Results In Hui population, the risk of prostate cancer for drinkers was 20.48 times higher than the non-drinkers (35.8%(19/53) to 5.7%(6/106), OR=20.48, 95%CI: 4.95-84.66) .The high level of F-PSA significantly increased the risk of prostate cancer for Hui group ( 83.0%( 44/53 ) to 55.7%( 59/106 ) , OR=4.27, 95%CI:1.18-15.43).In contrast, the high TG level decreased the risk of prostate cancer for Hui group (18.9%(10/53) to 20.8%(22/106), OR=0.24, 95%CI:0.07-0.83).In Han population, the risk of prostate cancer for smokers was 1.89 times higher than the non-smokers (55.1%(118/214) to 39.7%(170/428), OR=1.89,95%CI:1.28-2.78).Either high level of T-PSA or F-PSA increased the risk of prostate cancer for Han group (86.4%(185/214) to 53.7%(230/428),OR=2.34,95%CI:1.22-4.52;85.5%(183/214) to 56.1%(240/428), OR=2.43, 95%CI:1.29-4.59).However, the high TG level or high ratio of F/T-PSA decreased the risk of prostate cancer ( 15.4%( 33/214 ) to 18.7%( 80/428), OR=0.59, 95%CI:0.36-0.98;53.3%(114/214) to 73.4%(314/428), OR=0.53, 95%CI:0.36-0.78).The APRs of drinking and high level of F-PSA in Han populations were 66.6%,62.4%in Hui populations ,and the APRs of smoking and high level of T-PSA, high level of F-PSA were 33.8%,71.3%, 67.3% in Han populations.Conclusion Both drinking and high level of F-PSA might be the risky factors of prostate cancer while the high TG level might be protective factor for Hui group. However, for Han population, smoking, high T-PSA level, and high F-PSA level might be risky factors for prostate cancer while the high TG level and high ratio of F/T-PSA might be protective factors.In summary, the clinical relevant factors of prostate cancer may play different roles between Hui and Han populations in Ningxia region.
