The differences between three distinct locations of colorectal cancers based on clinicopathological characteristics and molecular features
10.3760/cma.j.issn.0253-9624.2014.12.012
- VernacularTitle:结直肠癌不同发病部位的临床及分子特征差异
- Author:
Cong LI
1
;
Zhimin WANG
;
Jiang ZHAO
;
Sanjun CAI
;
Ye XU
;
Fangqi LIU
Author Information
1. 复旦大学附属肿瘤医院大肠外科 复旦大学上海医学院肿瘤学系
- Keywords:
Colonic neoplasms;
Rectal neoplasms;
Pathology,molecular
- From:
Chinese Journal of Preventive Medicine
2014;(12):1078-1082
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the differences of clinical characteristics and molecular features among colorectal cancer subsides and provide evidence for colorectal cancer protection,diagnosis and treatment.Methods All of 4 316 colorectal patients from Shanghai cancer center were selected for clinical character analysis, among which, 2 224 subjects for molecular feature analysis.Clinic pathological characteristics like age, gender, tumor types, histological types, differentiation and T-stage, as well as molecular features like hMLH1,hMSH2,CD44,p21,p53,COX2,E-cadherin,Her2 and Ki-67,were involved into this research.Results It showed that compared with left-sided colon and rectal cancers, right-sided cancers occurred more in women ( 46.0% ( 541/1 176 ); 39.2% ( 424/1 083 ); 41.2% ( 848/2 057 ) , respectively,χ2 =11.85,P<0.01), had more mucinous or signet-ring carcinoma(12.0%(128/1 064), 5.8%(56/960),4.0%(75/1 859),respectively,χ2 =31.27,P <0.01), poor differentiated carcinoma (32.1%(343/1 069),19.5%(201/1 033), 19.3%(380/1 967),respectively,χ2 =72.66,P<0.01), and advanced T stage(87.9%(992/1 129), 83.2%(869/1 045), 72.2%(1 486/2 057),respectively,χ2 =121.44,P <0.01).Meanwhile,the rates of hMLH1 were higher in right-sided colon cancers when compared with rectal cancers ( 13.4% ( 59/439 ) vs 8.5% ( 88/1 035 ) , OR ( 95%CI ): 1.67 ( 1.18-2.37)),as well as the rates of hMSH2 negative expression(4.9% (22/452) vs 2.4% (26/1 083),OR (95%CI):2.08(1.17-3.71)).The rates of p53 positive expression were higher in right-sided colon cancers when compared with rectal cancers ( 76.2% ( 321/421 ) vs 68.4%, ( 776/1 134 ) , OR ( 95%CI ): 0.68 (0.52-0.87)).Compared with right-sided colon cancers,the rates of Her2 positive expression were higher in rectal cancers(19.3%(176/913) vs 13.2% (45/340),OR(95%CI):1.57 (1.10-2.23)),as well as the rates of Ki-67 expression which was positive in more than 50%cells (73.6%(840/1 141) vs 65.6%(299/456),OR(95%CI):0.68 (0.54-0.86)).Conclusion There are specific characteristics in right-sided colon cancers.The difference of molecular features between right-sided colon and rectal cancers are more significant.
