Study on risk factors of hepatitis C virus infection among Han population in Henan province
10.3760/cma.j.issn.0253-9624.2014.11.013
- VernacularTitle:河南省汉族居民丙型肝炎病毒感染的危险因素研究
- Author:
Jie LI
1
;
Yanmin MA
;
Wenjie YANG
;
Dingyong SUN
;
Qian ZHU
;
Zhe WANG
Author Information
1. 河南省疾病预防控制中心性病艾滋病防治研究所
- Keywords:
Hepatitis C;
Risk factor;
Case-control studies
- From:
Chinese Journal of Preventive Medicine
2014;(11):985-989
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the risk factors of hepatitis C Virus Infection among Han population in Henan Province , providing evidence for the development of targeted prevention and control measures .Methods In this 1∶1 matched case-control study, data of 134 cases and 134 controls were collected in seven hospitals from June 2013 to September 2013.Case group with the following conditions: Han nationality, first diagnosed hepatitis C in 2013, Current address and investigation belong to the same district ( county ) , above 18 years old;with the following conditions can′t into case group:not to cooperate with the investigation , late-stage Hepatitis C patients.Control group with the following conditions: Han nationality , with the matched case patients the same gender , in the same hospital for treatment ,from the same district ( county ) , the age difference ≤5 years old and in the same age group.With the following conditions can′t into control group:not to cooperate with the investigation , diagnosed with hepatitis B , hepatitis C patients.Collect 3 ml blood samples to test anti-HCV.Single factors were analyzed with χ2 between case and control , risk factors were analyzed with logistic regression model.Results The ratio about blood donation , blood transfusion,operation and acupuncture of cases were 35.1%(47/134),27.6%(37/134),42.5%(57/134),12.7%(17/134),with differences compared to those of controls (2.2%(3/134),5.2%(7/134), 21.6%(29/134),5.2%(7/134))(χ2 values were 47.60,24.47,13.42 and 4.58,all P values <0.05). Compared with those never received blood transfusion and those never donated blood , former blood receptors and blood donors had higher risk of hepatitis C infection ( OR:2.01,95%CI:1.32-3.05;OR:2.68,95%CI:1.85-3.88).Results of multiple nonconditional logistic regression analysis showed that Plasma donors and whole blood donors had higher risk of hepatitis C infection than those never donated plasma and blood ( OR:76.71,95%CI: 10.25-574.25; OR:10.23,95%CI: 2.15-48.70).Conclusion Blood transfusion and abnormal blood are independent risk factors among Han population in Henan Province of hepatitis C infection.The Plasma donors ,blood donors and with the increase in the times of blood transfusion , the risk of hepatitis C infection is increase.
