Analysis of the five-year effectiveness of highly active antiretroviral therapy among 200 HIV/AIDS patients in Jiangsu province
10.3760/cma.j.issn.0253-9624.2014.11.006
- VernacularTitle:江苏省200例 HIV 感染者和艾滋病患者抗病毒治疗5年效果分析
- Author:
Tao QIU
1
;
Ping DING
;
Xiaoyan LIU
;
Hongxiong GUO
;
Gengfeng FU
;
Xiaoqin XU
;
Xiping HUAN
;
Haitao YANG
Author Information
1. 江苏省疾病预防控制中心性病与艾滋病防制所
- Keywords:
Acquired immunodeficiency syndrome;
HIV;
Highly active antiretroviral therapy (HAART);
Effect
- From:
Chinese Journal of Preventive Medicine
2014;(11):947-952
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the five-year effectiveness of the people living with HIV/AIDS who initially received highly active antiretroviral therapy ( HAART ) in Jiangsu province.Methods HIV/AIDS initially received HAART from 1 Jan 2005 to 31 May 2014 in Jiangsu province with the CD 4 +T cell count tested in baseline ,6 months,1 year,2 years,3 years,4 years and 5 years after treatment initiation were selected.According to their retrospectively collected baseline and follow-up data, statistical analysis was performed using SPSS 16.0 software to analyze the variation of CD 4 +T counts and its impact factors in different times after treatment initiation.Results A total of 200 patients were included.A total of 134 patients were men ,and 66 were women , the ratio of male to female was 2.03∶1; mean age was ( 39.7 ± 10.3) years old;69.0%(138/200) of the patients married;53.0%(106/200) as the most were infected with HIV through heterosexual transmission,and followed by men who have sex with men(MSM) (25.5%, 51/200);taken together as 78.5%( 157/200 ).58.5%( 117/200 ) were treated in the CDC .The mean (95%CI) baseline CD4 +T cell count of cases was 106.9(93.3-120.5) cells/μl;the CD4 +T count tested in 6 months,1 year,2 years,3 years,4 years and 5 years after treatment initiation were 107.3,152.9,221.6, 260.0,281.3 and 316.4 cells/μl more than baseline respectively;the CD4 +T count after treatment initiation has increased over time(F=201.06,P<0.01).The mean(95%CI) CD4 +T count tested in 5 years after treatment initiation can increase to 540.7(445.4-635.9) cells/μl with a baseline CD4 +T count more than 200 cells/μl, but in the subgroups with a baseline CD 4+T count less than or equal to 50 cells/μl, 51-100 cells/μl, 101-150 cells/μl and 151-200 cells/μl,it only can reach to 431.4(375.9-487.0),400.0 (339.9-460.2),380.3(330.6-430.0)and 412.1(369.3-454.8) cells/μl respectively.The mean (95%CI) CD4 +T count tested in 5 years after treatment initiation with 1 baseline symptom categories can increase to 449.2(392.2-506.2)cells/μl, while 409.1 ( 317.8-500.5 ) cells/μl in the subgroup with baseline symptom categories more than or equal to 2.The CD4+T after treatment increased slowly associated with a lower baseline CD4 +T count level and more baseline symptom categories (F values were 3.96 and 2.35,P<0.01).Conclusion It has a remarkable effectiveness for HIV/AIDS treatment in Jiangsu province.The patients with a baseline CD 4 +T count more than 200 counts/μl have a better immune function recovery.
