Role of UHRF1 in methylation regulation and angiogenesis
10.3760/cma.j.issn.1003-9406.2020.02.025
- VernacularTitle:UHRF1基因在甲基化调控与血管新生中的作用
- Author:
Zi GUO
1
;
Zhaohui MO
Author Information
1. 中南大学湘雅三医院内分泌科
- Keywords:
UHRF1 gene;
Epigenetic regulation;
DNA methylation;
Histone methylation;
Angiogenesis
- From:
Chinese Journal of Medical Genetics
2020;37(2):200-204
- CountryChina
- Language:Chinese
-
Abstract:
Many recent studies have proved that ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is an important nuclear protein associated with tumorigenesis,which plays a significant role in epigenetic regulation,especially in DNA methylation and histone methylation.For its particular domains,UHRF1 plays a critical role in biological behaviors including cell proliferation,cell cycle,and apoptosis.Overexpression of UHRF1 in various tumors is closely associated with the angiogenesis in tumors.This paper will provide a review of the regulation of UHRF1 in DNA methylation and histone methylation,and discuss the potential epigenetic role of UHRF1 in angiogenesis.
