Research status of the tumor stroma ratio in prognosis and treatment of pancreatic cancer
10.3760/cma.j.cn112139-20240414-00183
- VernacularTitle:肿瘤间质比与胰腺癌治疗及预后关系的研究现状
- Author:
Zhiyao FAN
1
;
Bohan SU
;
Hanxiang ZHAN
Author Information
1. 山东大学齐鲁医院胰腺外科，济南 250012
- Keywords:
Pancreatic neoplasms;
Antineoplastic protocols;
Stroma ratio;
Tumor microenvironment;
Prognosis;
Chemotherapy
- From:
Chinese Journal of Surgery
2024;62(10):976-980
- CountryChina
- Language:Chinese
-
Abstract:
An increasing number of studies suggested that the tumor microenvironment exerts a substantial influence on the pathophysiology of pancreatic cancer. As a crucial component of the tumor microenvironment,the tumor stroma plays a pivotal role in the occurrence,development,and chemotherapy resistance of pancreatic cancer. By serving as a proxy for the interaction between tumor cells and the microenvironment,the tumor stroma ratio(TSR) has emerged as a focal point of investigation in recent years. At present,numerous studies show that a low TSR is a protective factor for the prognosis of resectable pancreatic cancer. Additionally, patients with a low TSR are more suitable for the gemcitabine and albumin-bound paclitaxel chemotherapy regimen. But these researches are not conclusive, and there is still a gap between guiding precision treatment. Further research and exploration are required. Integration of artificial intelligence deep learning models into traditional pathological and imaging assessments facilitates precise evaluation of the TSR. It can also enable stratification and precision treatment of pancreatic cancer patients based on this index.
