Progress of genomic mutation spectrum in biliary tract malignant tumors
10.3760/cma.j.cn112139-20230518-00208
- VernacularTitle:胆道恶性肿瘤的基因组突变谱研究进展
- Author:
Shimei QIU
1
;
Fatao LIU
;
Wenguang WU
;
Yingbin LIU
Author Information
1. 上海理工大学健康科学与工程学院，上海 200093
- Keywords:
Biliary tract cancer;
Gallbladder neoplasms;
Intrahepatic cholangiocarcinoma;
Extrahepatic cholangiocarcinoma;
Genome;
Mutation
- From:
Chinese Journal of Surgery
2023;61(12):1124-1129
- CountryChina
- Language:Chinese
-
Abstract:
Biliary tract cancer is characterized by high invasiveness, occult early clinical manifestations and rapid progression. Surgical resection typically fails to achieve satisfactory outcomes. Biliary tract cancer exhibits low sensitivity to radiotherapy and chemotherapy. The prognosis of patients is extremely poor. Genomics research based on next-generation sequencing technology has made some advances. The gene mutation spectrum of biliary tract cancer has been preliminarily revealed, which lays a foundation for the study of molecular typing. This review summarizes the research progress and clinical application of gene mutation spectrum of biliary tract cancer in recent years, aiming to provide reference for the clinical diagnosis, treatment and basic research.
