Living-donor intestinal transplantation
10.3760/cma.j.cn112139-20230223-00080
- VernacularTitle:活体小肠移植术
- Author:
Guosheng WU
1
;
Zhaoxu LIU
;
Long ZHAO
;
Tingbo LIANG
Author Information
1. 浙江大学医学院第一附属医院结直肠外科暨小肠移植中心，杭州 310002
- Keywords:
Organ transplantation;
Intestine, small;
Living donors;
Short bowel syndrome;
Intestinal failure
- From:
Chinese Journal of Surgery
2023;61(10):850-855
- CountryChina
- Language:Chinese
-
Abstract:
Due to advances in surgical techniques, perioperative care, and new immunosuppressive agents, intestinal transplantation has become a valid therapeutic choice for chronic intestinal failure. Intestinal transplantation has been performed most commonly using deceased donation, while less than 2% of which have been from living donation. Living donor intestinal transplantation obtaining a segmental intestinal graft, usually from close relatives. Preliminary results show that acute/chronic rejection rates, postoperative opportunistic infections, and graft versus host disease are significantly reduced after living donor intestinal transplantation, contributing to improved graft and patient survivals. Due to a severe shortage of organ donation, especially in children, living donor intestinal transplantation has increasingly become an important treatment option for patients with chronic intestinal failure in China.
