Polymorphisms of the CYP1A1 and GSTM1 genes and their combined effects on individual susceptibility to lung cancer in a Chinese population
- VernacularTitle:中国人CYP1A1和GSTM1基因多态性及其对个体肺癌易感性的联合效应
- Author:
Kaixian XUE
1
;
Lin XU
;
Senqing CHEN
;
Guojian MA
;
Jianzhong WU
Author Information
1. Cancer Institute of Jiangsu Province
- From:
Chinese Journal of Medical Genetics
2001;18(2):125-127
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the polymorphisms of CYP1A1 and GSTM1 genes as well as their separate and combined effects on individual susceptibility to lung cancer. Methods This study was conducted in Jiangsu Province. In the matched 106 pairs of patients with lung cancer and non-cancer control persons,genomic DNA were prepared from peripheral blood samples. The genotypes of CYP1A1 Ile/Val and GSTM1+/0 polymorphisms were detected by the allele-specific (AS)-PCR and multi-differential(MD)-PCR. Results Individuals with genotype Val/Val of CYP1A1,genotype 0/0 of GSTM1, combined genotypes GSTM1 0/0 and CYP1A1 Val/Val, or combined genotypes GSM1 0/0 and CYP1A1 Ile/Val had higher relative risk than those with the corresponding common genotypes and combined genotypes; their odds ratios were 4.02(P=0.03), 1.92(P=0.019), 9.38(P=0.04) and 3.27(P=0.01), respectively. Conclusion There is a synergy of susceptible genotypes GSTM1 0/0 and CYP1A1 Val/Val or CYP1A1 Ile/Val to enhance the individual susceptibility to lung cancer.
