Polymorphism of MAO-B gene and NAD(P)H: quinone oxidoreductase gene in Parkinson's disease
- VernacularTitle:单胺氧化酶B和NAD(P)H醌氧化还原酶基因多态性与帕金森病的关系
- Author:
Ming SHAO
1
;
Zhoulin LIU
;
Enxiang TAO
;
Biao CHEN
Author Information
1. Zhujiang Hospital of the First Military Medical University
- From:
Chinese Journal of Medical Genetics
2001;18(2):122-124
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether Parkinson's disease(PD) is associated with genetic polymorphism of intron 13 of monoamine oxidase B(MAO-B) and NAD(P)H: quinone oxidoreductase(NQO1) gene cDNA 609C to T. Methods Association study was performed in 126 PD patients and 136 healthy control subjects matched for age, sex and origin. The NQO1 gene polymorphism was analyzed with the polymerase chain reaction-restriction fragment length polymorphism, the polymorphism of intron 13 of MAO-B was analyzed by allele-specific PCR. Results The allelic frequency of the mutant T allele of NQO1 gene was significantly higher in the PD patients as compared to the controls(P<0.05). The relative risk of suffering from PD increased (OR=3.8) in the individuals with T allelic genotype of NQO1 gene, and the odds ratio was as high as 5.7 when the individuals with A or AA genotype of MAO-B gene coexisted with the T allele genotype of NQO1 gene. Conclusion The cDNA 609T allele of NQO1 gene might be a risk factor of PD, which could be associated with the genetic susceptibility of PD. The high activity A or AA genotype of MAO-B and the low activity genotype of NQO1 gene might have synergistic effect. When both genotypes coexist, the risk of suffering PD will be increased greatly.
