Gene Ploymorphisms of Angiotensin Converting Enzyme and Endothelial Nitric Oxide Synthase in Patients with IgA Nephropathy.
- Author:
In Hee KIM
;
Won KIM
;
Sung Kyew KANG
;
Dae Yul LEE
;
Gou Young KOH
;
Kwang Young LEE
;
Sung Bae PARK
;
Hyun Chul KIM
;
Sung Kwang PARK
- Publication Type:Original Article
- Keywords:
IgA Nephropathy;
Angiotensin Converting Enzyme Gene;
Endothelial Nitric Oxide Gene;
Ploymorphism
- MeSH:
Angiotensins*;
Genotype;
Glomerulonephritis, IGA*;
Humans;
Hypertension;
Immunoglobulin A*;
Incidence;
Kidney Failure, Chronic;
Nitric Oxide Synthase Type III*;
Peptidyl-Dipeptidase A*;
Proteinuria;
Sclerosis
- From:Korean Journal of Nephrology
1999;18(3):390-399
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To evaluate the association between ACE gene I/D polymorphism and ecNOS gene a/b polymorphism in IgA nephropathy, 158 IgA nephropathy patients and 121 control subjects were examined. In genotype distribution of the ACE gene I/D polymorphism, there was no significant difference in genotype distribution between controls and IgA nephropathy patients. We also examined the association between ACE genotype and clinical characteristics in the patients with IgA nephropathy. The incidence of hypertension in patients with DD genotype was higher than that of other genotypes. There were no significant association between I/D polymorphism distribution and chronic renal failure, nephrotic range proteinuria, and glomerular sclerosis in IgA nephropathy. In genotype distribution of ecNOS gene a/b polymorphism, there was no significant difference between IgA nephropathy patients and controls. There was no significant difference in frequency of chronic renal failure, hypertension, nephrotic range proteinuria and glomerular sclerosis among ecNOS genotypes. In addition, we failed to detect any significant association between the ACE and ecNOS gene-polymorphis ms and the decline of renal function in IgA nephropathy. A further study with larger number of patient population would be necessary.
