Progress in researches on the relationship between genetic polymorphisms of alcohol-metabolizing enzymes and cancers
10.3760/j.issn:1003-9406.2001.01.018
- VernacularTitle:乙醇代谢酶基因多态与肿瘤关系研究进展
- Author:
Zhumei ZHANG
1
;
Jianchao BIAN
Author Information
1. Shanghai Medical University
- From:
Chinese Journal of Medical Genetics
2001;18(1):62-65
- CountryChina
- Language:Chinese
-
Abstract:
Genetic polymorphism of carcinogen-metabolizing enzymes is one of the important aspects of the genetic susceptibility to cancer. The enzymes involved in alcohol metabolism include mainly alcohol dehydrogenase(ADH), aldehyde dehydrogenase(ALDH) and cytochrome P450 2E1(CYP2E1), which all appear to be polymorphic. Several recent studies show that the genetic polymorphisms of alcohol-metabolizing enzymes are associated with some cancers such as liver cancer, stomach cancer and esophageal cancer. But there are also the inconsistent results.
