Single nucleotide polymorphism in β2-adrenoceptor gene and the distribution in Chinese Han ethnic group

VernacularTitle:β2-肾上腺素能受体基因单核苷酸多态性及在汉族人群中的分布
Author: Hong WU ¹ ; Gangming CAI ; Hongyan XU ; Hua CHEN ; Junhua XIAO ; Daru LU ; Jinglun XUE ; Xingfang QIU ; Li JIN
Author Information

1. 复旦大学
From: Chinese Journal of Medical Genetics 2001;18(1):1-3
CountryChina
Language:Chinese
Abstract: Objective　The study was conducted to investigate single nucleotide polymorphism(SNP) in beta2-adrenoceptor(β2-AR) gene and the distribution of these identified SNPs in Chinese Han ethnic group.Methods　β2-AR gene was sequenced to detect SNPs by fluorescent labeling automatic sequencing method in 80 unrelated samples from territory of Dabie Mountain in Anhui province.Results A total of 8 SNPs were identified in length of 3.8 kb, including 5 SNPs in code region, 3 SNPs in regulatory region. Although the variations, -468C to G, -367T to C, -47C to T,-20T to C,+79C to G,+100G to A,+491C to T,+1098T to C have been identified in other ethnic groups, they have not been found in our study. The allele distribution of SNPs is in good unity with the Hardy-Weinberg equilibrium.Conclusion　The distribution of SNPs in β2-AR gene is not equable and the SNPs in different ethnic groups differ greatly. The allele distribution of SNPs conforms well to the Hardy-Weinberg equilibrium.