Clinical application progress of bioresorbable vascular scaffolds in lower extremities arteriosclerotic obliterans
10.3760/cma.j.cn112139-20210120-00043
- VernacularTitle:生物可降解血管支架在下肢动脉硬化闭塞症中的临床应用进展
- Author:
Kun ZHANG
1
;
Zhong CHEN
;
Zhongzhou HU
;
Huanqin ZHENG
Author Information
1. 首都医科大学附属北京安贞医院血管外科 100029
- Keywords:
Arteriosclerosis obliterans;
Lower extremity;
Prostheses and implants;
Angioplasty;
Absorbable
- From:
Chinese Journal of Surgery
2021;59(12):1032-1036
- CountryChina
- Language:Chinese
-
Abstract:
Endovascular technology has become the first choice for the treatment of lower extremities arteriosclerotic obliterans. Bioresorbable vascular scaffolds have attracted more and more attention as a choice of endovascular technology. In the last decade, poly(L-lactic acid) bioresorbable scaffolds with or without drug coating have shown acceptable medium and long-term safety and efficacy in lower extremities arteriosclerotic obliterans, but the lesions of the subjects were relatively simple. Magnesium alloy bioresorbable scaffolds are safe but less effective in the treatment of lower extremities arteriosclerotic obliterans. Both iron and zinc alloy bioresorbable scaffolds have shown considerable results in animal experiments. In particular, the success of implantation of drug-coated iron alloy bioresorbable scaffolds in below-the-knee artery indicated that the iron alloy bioresorbable scaffolds have officially entered the clinical trial stage. Through the comprehensive summation of the previous clinical and experimental data of bioresorbable vascular scaffolds and the pathological characteristics of lower extremities arteriosclerotic obliterans, it is shown that the drug-coated poly(L-lactic acid) bioresorbable scaffolds and iron alloy bioresorbable scaffolds will have greater development potential in the treatment of lower extremities arteriosclerotic obliterans.
