Change in Plasma Homocysteine Concentration during the Recovery Phase of Renal Transplantation.
- Author:
Jin Ho JEON
;
Dong Ho YANG
;
Sea Yong HONG
- Publication Type:Original Article
- Keywords:
Homocyteine;
Kidney transplantation;
Cyclosporine
- MeSH:
Creatinine;
Cyclosporine;
Folic Acid;
Homocysteine*;
Hyperhomocysteinemia;
Kidney;
Kidney Transplantation*;
Plasma*;
Prospective Studies;
Vitamin B 12;
Vitamin B 6
- From:Korean Journal of Nephrology
1999;18(3):476-482
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A prospective study of vitamin B6, B12, folate, and homocysteine levels was carried out in 7 kidney transplant(KT) recipients. The first sample for the basal level was drawn on the morning of the KT day before the start of cyclosporine injection. Thereafter, serial blood samples were taken every day until the serum creatinine level decreased below 1.5 mg/dl and then every 2 or 3days until discharge. The serum creatinine level decreased to below 1.5 mg/dl within 3days except for cases 4 and 6. The homocysteine levels decreased markedly in synchronisation with serum creatinine levels increased during the first 7days and then declined together with serum creatinine levels but went up again after a few days. The levels of B6, and vitamin B12 do not continue to decrease after the levels of serum creatinine have decreased to 1.5mg/dl, while homocysteine levels go up progressively. In conclusion, contrary to our expectation, the level of homocysteine rebounds a few days after KT following a transient decline. A deficiency of folic acid, vitamin B6 and vitamin B12 does not seem to cause hyperhomocysteinemia in KT recipients. It is necessary to pay attention to hyperhomocysteinemia in KT recipients, especially when the recipients have an atherosclerosis-related complication.
