Proposal and Analysis of"Ternary"Model of Sensitization for Proton Therapy
10.12455/j.issn.1671-7104.230563
- VernacularTitle:质子治疗"三元"增敏模型的提出及分析
- Author:
Xiaowa WANG
1
,
2
,
3
;
Xufei WANG
;
Ning DU
;
Lan WANG
Author Information
1. 上海市质子重离子医院,上海市,201321
2. 上海市放射肿瘤学重点实验室,上海市,201321
3. 上海质子重离子放射治疗工程技术研究中心,上海市,201321
- Keywords:
proton therapy;
boron neutron capture therapy;
proton boron capture therapy;
"ternary"model
- From:
Chinese Journal of Medical Instrumentation
2024;48(3):271-276
- CountryChina
- Language:Chinese
-
Abstract:
In order to improve the biological effect of proton therapy,the authors first propose a new method of boron-based proton-enhanced radiotherapy in a"ternary"radiotherapy mode,based on the existing sensitizing effect of proton radiotherapy:i.e,Boron-based mediators(11B and 10B)induce the proton-hydrogen-boron fusion reaction of the low-energy protons arriving at the Bragg peak region of the tumor target area(p+11B→3α)and thermal neutron capture(10B+n→7Li3+(0.84 MeV)+4He2+(1.47 MeV)+γ(0.477 MeV)),which release low-energy α-particles with high LETs to enhance the biological effect of proton dose in the target area,thus improve the clinical effect of proton therapy.Then,the advantages and disadvantages of the"ternary"model were analyzed from the theoretical basis and current research status,and finally,the"ternary"model is summarized and prospected.
