Effects of Galantamine Treatment on Attention, Activities of Daily Living, and Neuropsychiatric Symptoms between the Patients with Pure Alzheimer's Disease and Mixed Dementia.
- Author:
Hyo Shin KANG
1
;
Ji Hae YUN
;
Inn Sook AHN
;
Yu Jin MOON
;
Tae Young HWANG
;
Young Min LEE
;
Hyeran KIM
;
Doh Kwan KIM
Author Information
1. Clinical Research Center, Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea. paulkim@skku.edu
- Publication Type:Original Article
- Keywords:
Alzheimer's disease;
Mixed dementia;
Galantamine;
Attention;
Clinical efficacy
- MeSH:
Activities of Daily Living;
Alzheimer Disease;
Attention;
Behavioral Symptoms;
Cognition;
Dementia;
Galantamine;
Humans;
Mass Screening
- From:Journal of Korean Geriatric Psychiatry
2012;16(1):24-30
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The purpose of this study was to compare the efficacy of galantamine treatment, especially attention ability between patients with pure Alzheimer's disease (AD) and Mixed dementia (MD) during a 24-week trial. METHODS: A total of 40 patients were recruited for this 24-week study. The effect of galantamine on attention was measured using Seoul Computerized NeuroCognitive Function Test (SCNT) and frontal functions test of Seoul Neuropsychological Screening Battery (SNSB). Patients'activities of daily living using the Seoul-Activities of Daily Living (S-ADL) and the Seoul-Instrumental Activities of Daily Living (S-IADL) ; behavioral symptoms using the Korean version Neuropsychiatric Inventory (K-NPI) were measured at baseline and 24-week. RESULTS: 17 pure AD patients and 23 MD patients were analyzed in this study. Attention as measured by SCNT was not significantly different from baseline after 24 weeks of treatment in both groups. There was no significant difference between two groups in mean change from baseline in the SCNT, S-ADL, S-IADL and K-NPI scores at 24-week. CONCLUSION: Galantamine showed a therapeutic effect on cognition, activities of daily living, neuropsychiatric symptoms in pure AD and MD. Furthermore, Galantamine may specifically help to maintain attention and it may have positive effects on other cognitive and functional abilities.
