Conversion therapy of biliary tract cancer from the perspective of tumor heterogeneity
10.3760/cma.j.cn112139-20210105-00006
- VernacularTitle:从异质性角度看胆道恶性肿瘤的转化治疗
- Author:
Zhaohui TANG
1
;
Xiaopeng YU
;
Huanjun TONG
;
Zhiwei QUAN
Author Information
1. 上海交通大学医学院附属新华医院普外科 200092
- Keywords:
Biliary tract cancer;
Conversion therapy;
Heterogeneity
- From:
Chinese Journal of Surgery
2021;59(4):260-264
- CountryChina
- Language:Chinese
-
Abstract:
Biliary tract cancer is found in the middle and advanced stages mostly and patients will deprive surgical indications. Conversion therapy can make the stage of some patients down and thus make radical resection feasible. Biliary tract cancer is highly heterogeneous in clinical features, cell origin, histology, molecular biology and other aspects, resulting in a lack of specific and effective conversion therapy strategies. Currently, it is the important development direction to evaluate and classify different individual conditions and select individualized conversion therapy regimens. With the deepening of the research on the pathogenesis and the improvement of treatment protocols, the future conversion therapy will undoubtedly develop towards the direction of individualization and precision.
