The role of three-dimensional chromatin structure changes in tumor progression
10.3760/cma.j.cn112139-20200319-00240
- VernacularTitle:染色质三维结构变化在肿瘤进展中的作用
- Author:
Guoqiang LI
1
;
Fatao LIU
;
Yingbin LIU
Author Information
1. 上海交通大学医学院附属仁济医院胆胰外科 上海市胆道疾病重点实验室 上海市胆道疾病研究中心 200092
- Keywords:
Chromosome structures;
Neoplasms;
Topological domains;
Copy number variation
- From:
Chinese Journal of Surgery
2020;58(12):973-976
- CountryChina
- Language:Chinese
-
Abstract:
The human genome is not a linear structure, but a three-dimensional structure through complex folding and assembly. Chromosome structure capture technology can detect the three-dimensional construction of chromatin. Hi-C sequencing data of various tumors indicate that the chromatin topology associated domains changed during tumor progression and is related to copy number variation. In addition, transformation of the genomic compartment is related to gene expression. However, current researches on three-dimensional structures of tumoral chromatin are still in the stage of exploration, and some conclusions are too superficial to be applied to the clinic immediately, which requires further study.
