Numerical Investigation of Particle Deposition in Human Nasal Cavity for Different Parameters of Spay Device

VernacularTitle:喷雾参数对鼻腔内药物颗粒分布影响的数值模拟研究
Author: Wenxia DU ¹ ; Zhuangyuan MENG ; Hong GUO ; Shengzhang WANG ; Wenping LI
Author Information

1. 青海省第五人民医院呼吸科
Keywords: rhinitis disease; drug delivery; nasal spray device; computational fluid dynamics; particle deposition
From: Chinese Journal of Medical Instrumentation 2017;41(2):100-102,106
CountryChina
Language:Chinese
Abstract: Whether the drug is successfuly transported to the focus area is the key to the treatment of the rhinitis disease. The efficiency of drug delivery is dependent on the design of nasal spray device. A three-dimensional model of nasal cavity was constructed from the head CT image data of a healthy human subject. The deposition of drug particles was simulated numericaly by Computational Fluid Dynamics technique. The main variables of the study were the size and density of drug particles, the injecting speed of drugs etc. In conclusion, with the increase of particle intensity and injection speed, the deposition of particles in the affected area trends to increase after first slow decrease.