Greater prevalence of seropositivity for anti-cyclic citrullinated peptide antibody in unaffected first-degree relatives in multicase rheumatoid arthritis-affected families.
10.3904/kjim.2013.28.1.45
- Author:
Seong Kyu KIM
1
;
Jisuk BAE
;
Hwajeong LEE
;
Ji Hun KIM
;
Sung Hoon PARK
;
Jung Yoon CHOE
Author Information
1. Department of Internal Medicine, Arthritis and Autoimmunity Research Center, Catholic University of Daegu School of Medicine, Daegu, Korea. jychoe@cu.ac.kr
- Publication Type:Original Article
- Keywords:
Rheumatoid arthritis;
First-degree relative;
Rheumatoid factor;
Citrullinated antigen
- MeSH:
Adolescent;
Adult;
Arthritis, Rheumatoid/blood/*epidemiology/genetics/*immunology;
Autoantibodies/*blood;
Biological Markers/blood;
Case-Control Studies;
Chi-Square Distribution;
Cross-Sectional Studies;
Female;
Gene-Environment Interaction;
Genetic Predisposition to Disease;
Humans;
Logistic Models;
Male;
Middle Aged;
Multivariate Analysis;
Odds Ratio;
Pedigree;
Peptides, Cyclic/*immunology;
Republic of Korea/epidemiology;
Risk Factors;
Seroepidemiologic Studies;
Vimentin/immunology;
Young Adult
- From:The Korean Journal of Internal Medicine
2013;28(1):45-53
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: This study determined the prevalence and determinants of seropositivity for rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP) antibody, and anti-mutated citrullinated vimentin (anti-MCV) antibody in unaffected first-degree relatives (FDRs) of rheumatoid arthritis (RA) patients. METHODS: A total of 337 subjects (135 with RA and 202 FDRs) were enrolled in this case-control study. Serum RF, anti-CCP antibody, and anti-MCV antibody were assayed. Subjects in multicase families (> or = 2 affected FDRs within the same family) were identified. Multivariate logistic regression analysis was used to identify risk factors associated with RA-related autoantibodies. RESULTS: Seropositivity for RF, anti-CCP antibody, or anti-MCV antibody was detected in 14.4%, 5.0%, or 13.4% of unaffected FDRs, respectively. Anti-CCP antibody seropositivity was more prevalent in FDRs in multicase families (17.8%) than in those not in multicase families (1.3%, p < 0.0001). Significant correlations between RA-associated autoantibodies were detected in the FDR group (between RF and anti-CCP antibody: r = 0.366, p < 0.0001; between RF and anti-MCV antibody: r = 0.343, p < 0.0001; and between anti-CCP antibody and anti-MCV antibody: r = 0.849, p < 0.0001). After adjustment for age and sex, anti-CCP antibody seropositivity in FDRs was significantly associated with being in a multicase family (odds ratio, 49.8; 95% confidence interval, 5.6 to 441.6). CONCLUSIONS: The association between anti-CCP antibody seropositivity in unaffected FDRs and being in a multicase family suggests that genetic and/or environmental factors may increase the risk for RA development in unaffected FDRs.
