Clinical characteristics of interferon-gamma-inducible protein of 10 kDa in children with wheezing.
10.4168/aard.2016.4.3.174
- Author:
Beom Joon KIM
1
;
Kil Seong BAE
;
Hwan Soo KIM
;
Yoon Hong CHUN
;
Jong Seo YOON
;
Hyun Hee KIM
;
Jin Tack KIM
Author Information
1. Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. hhkped@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Interferon-gamma-inducible protein of 10 kDa;
Wheezing;
Child
- MeSH:
Asthma;
Bronchiolitis;
Chemokine CXCL10*;
Child*;
Emergency Service, Hospital;
Enzyme-Linked Immunosorbent Assay;
Eosinophils;
Humans;
Inflammation;
Lung;
Respiratory Sounds*;
Respiratory Tract Infections;
Thorax
- From:Allergy, Asthma & Respiratory Disease
2016;4(3):174-180
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Recent studies have shown that interferon-gamma-inducible protein of 10 kDa (IP-10/CXCL10) levels is increased in acute bronchiolitis and asthma. The aim of this study was to examine the levels of IP-10 in children with wheezing and whether it correlates with other clinical variables. METHODS: A total of 62 subjects children were hospitalized for lower respiratory tract infection with wheezing and visited the Emergency Department due to an acute exacerbation of asthma. IP-10 levels were measured using enzyme-linked immunosorbent assay in the serum collected at admission. Serum IP-10 levels were evaluated for the relationships with age, sex, blood eosinophils counts, acute phase reactant, allergic sensitization, history of wheezing, and chest X-ray findings. RESULTS: Age showed a significant negative correlation with serum IP-10 levels (P=0.002). The serum levels of IP-10 were also significantly increased in patients with pneumonic infiltration on X-rays compared to those with normal or hyperinflation (P<0.009). There was no significant difference in the serum IP-10 level according to the other factors, including allergic sensitization. CONCLUSION: Serum IP-10 is significantly associated with inflammation of the lung and age, but not with allergic inflammation.
