Effects of the properties and modifications of biomaterials on foreign body response
10.3760/cma.j.cn114453-20231024-00127
- VernacularTitle:生物材料的性质及其修饰对异物反应的影响
- Author:
Yichen ZHAN
1
;
Guo ZHANG
;
Zhenxing WANG
;
Jiaming SUN
Author Information
1. 华中科技大学同济医学院附属协和医院整形外科，武汉 430022
- Keywords:
Foreign body reaction;
Biomaterial;
Implants;
Macrophage;
Fibrosis
- From:
Chinese Journal of Plastic Surgery
2024;40(11):1228-1235
- CountryChina
- Language:Chinese
-
Abstract:
Biomaterials have gained substantial attention in the field of regenerative medicine and shown respectable potential in clinical translation. However, the function of biomaterials is hindered by the fibrotic encapsulation of foreign body response (FBR) under some circumstances. FBR also lowers the expected service life of implanted devices and causes pain, distortion of tissue or even malignant diseases. Therefore, the mechanism of FBR and the modulating factors need to be further investigated to improve the tissue biocompatibility of biomaterials. This article reviewed the process of FBR, summarized the properties and modification of biomaterials related to FBR, and discussed strategies to mitigate this immune reaction.
