Rapid desensitization to isoniazid and rifampin in an adolescent with active pulmonary tuberculosis.
10.4168/aard.2016.4.3.212
- Author:
Heirim LEE
1
;
Min Sun KIM
;
Hea Kyoung YANG
;
Minji KIM
;
Ji Young LEE
;
Jong Min KIM
;
Ji Man KANG
;
Yae Jean KIM
;
Kangmo AHN
;
Jihyun KIM
Author Information
1. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jhlovechild@gmail.com
- Publication Type:Case Report
- Keywords:
Immunologic desensitization;
Antitubercular agents;
Drug hypersensitivity
- MeSH:
Adolescent*;
Antitubercular Agents;
Desensitization, Immunologic;
Drug Hypersensitivity;
Ethambutol;
Exanthema;
Humans;
Hypersensitivity;
Isoniazid*;
Male;
Pruritus;
Pyrazinamide;
Rifampin*;
Tuberculosis;
Tuberculosis, Pulmonary*
- From:Allergy, Asthma & Respiratory Disease
2016;4(3):212-216
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hypersensitivity reactions to antituberculosis medicine are obstacles to the treatment of tuberculosis. However, rapid drug desensitization can secure successful treatment with essential antituberculosis medicines in pediatric patients. A 17-year-old boy with active pulmonary tuberculosis complained of generalized erythematous rashes, pruritus on the 11th day of tuberculosis treatment. He was diagnosed with hypersensitivity reactions to isoniazid and rifampin by the oral provocation test. After desensitization, the patient continued to take antituberculosis treatment with isoniazid, rifampin, pyrazinamide, and ethambutol. We report here a case of successful desensitization in an adolescent with hypersensitivity to isoniazid and rifampin.
