Research and application of adipose-derived mesenchymal stem cells in immune regulation

VernacularTitle:脂肪源性间充质干细胞免疫调节作用的研究与应用
Author: Tianyi SUN ¹ ; Feng LU ; Cheng ZHOU ; Ziqing DONG ; Bin LI
Author Information

1. 南方医科大学南方医院整形美容外科，广州　510515
Keywords: Mesenchymal stem cells; Immunomodulatory; Cytokines; Extracellular vesicles; Immune cells
From: Chinese Journal of Plastic Surgery 2024;40(2):227-234
CountryChina
Language:Chinese
Abstract: Adipose-derived mesenchymal stem cell (ADSC) has become a research hotspot in the field of regenerative medicine and stem cells in recent years because of its rich stock, easy access and low immunogenicity. ADSC can regulate immune system not only directly by interacting with immune cells, such as T cells, macrophages and B cells, but also indirectly via secreting soluble cytokines, such as interleukin (IL), growth factors and extracellular vesicles. Meanwhile, the immunomodulatory effects of ADSC have been demonstrated in vitro and in vivo experiments and applied to treat various of immune-related diseases with good results, such as systemic scleroderma, systemic lupus erythematosus and atopic dermatitis, etc. In this article, the direct and indirect immunomodulatory mechanisms and clinical applications of ADSC are described, its research direction and application prospect are also prospected.