Research progress of long non-coding RNA in venous malformations
10.3760/cma.j.cn114453-20231113-00212
- VernacularTitle:长链非编码RNA在静脉畸形中的研究进展
- Author:
Haoran ZHANG
1
;
Junjie LIN
;
Junbo QIAO
Author Information
1. 郑州大学第三附属医院血管瘤外科河南省血管瘤与血管畸形重点实验室，郑州 450003
- Keywords:
Venous malformation;
Long non-coding RNA;
Gene regulation;
Vascular endothelium
- From:
Chinese Journal of Plastic Surgery
2023;39(11):1167-1169
- CountryChina
- Language:Chinese
-
Abstract:
Long non-coding RNA (lncRNA) is a kind of non-coding RNA with a length of more than 200 nucleotides mainly distributed in a variety of eukaryotic cells. It cannot encode proteins itself. With the development of gene sequencing technology, the clinical understanding of venous malformation, molecular pathogenesis of vascular malformation, is getting deeper and deeper. Abnormal expression of lncRNA may be closely related to the occurrence and development of venous malformations. LncRNA can selectively regulate the proliferation, apoptosis and migration of endothelial cells and vascular smooth muscle cells, thus affecting the occurrence and development of venous malformations. Therefore, lncRNA is expected to be a novel diagnostic marker or a new therapeutic target for venous malformations.
