Expression ind significance of MMP2 and type IV collagen in gastric cancer
10.3760/j:issn:0529-5815.2000.10.016
- VernacularTitle:基质金属蛋白酶及Ⅳ型胶原在胃癌中的表达及其意义
- Author:
Guosheng FENG
1
;
Yuquan TAN
Author Information
1. Railway General Hospital of Beijing
- Keywords:
Stomach neoplasms;
Metalloproteinases;
Gene expression
- From:
Chinese Journal of Surgery
2000;38(10):775-777
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between the expression of MMP2, type IV callagen, and invasion and metastasis of gastric cancer． Mothods The expression of MMP2 and Type IV collagen was observed by using immunohistochemistry technique． Results The MMP2 expression clearly appeared in the poordifferentiated adenocarcinoma and tubular adenocarcinoma(85．7 %, 77．7 % )． Type IV collagen destruction was observed simultaneously． MMP2 was highly expressed in patients with cancer embolus in blood vessel and lymphatic vessel or with lymph node metastasis (83．3 %, 86．7 % )． Conclutions The high expression of MMP2 was significantly associated with infiltration and metastasis of gartric cancer． The extracellular matrix, especially type IV collagen was destructed in the cases of high expression of MMP2． These rusults suggest that monitoring the level of MMP2 expression may be an index for evaluation of prognosis．
