The infiltration landscape of common immune cells in the microenvironment of melanoma
10.3760/cma.j.cn114453-20220210-00034
- VernacularTitle:黑色素瘤微环境中常见免疫细胞浸润图谱
- Author:
Kangjie SHEN
1
;
Chuanyuan WEI
;
Jianying GU
Author Information
1. 复旦大学附属中山医院整形外科，上海 200032
- Keywords:
Melanoma;
Tumor microenvironment;
Immune cells
- From:
Chinese Journal of Plastic Surgery
2023;39(9):1013-1019
- CountryChina
- Language:Chinese
-
Abstract:
Melanoma is the skin malignancy with high potential of metastasis, and its morbidity rate is increasing every year. Melanoma patients exhibit a significantly elevated tumor mutational burden, with a higher prevalence of neoantigenic epitopes, leading to widespread activation of immune cells. Consequently, melanoma demonstrates a favorable response rate to immunotherapy. In this study, the infiltration landscape of common immune cells and their function in the melanoma microenvironment were depicted and analyzed. This study contributes to a better understanding among clinical practitioners of the role of the immune system in the development and progression of melanoma, and provides valuable guidance for the development of novel immunotherapeutic agents.
