The mechanism of biological adaptability of peripheral nerves during limb lengthening in rabbits
10.3760/j:issn:0529-5815.2000.10.005
- VernacularTitle:缓慢牵伸肢体延长时周围神经生物学适应性机理的实验研究
- Author:
Jianzhong XU
1
;
Qihong LI
;
Shaodi FAN
Author Information
1. Southuest Hospaital , Third Military Medical University
- Keywords:
Bone lengthening;
Peripheral nerves;
Histology;
Animals,laboratory
- From:
Chinese Journal of Surgery
2000;38(10):739-741
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanism of subclinical damage and repairing process of peripheral nerves during gradual tibial lengthening． Mothods Histological investigation,electrophysiological examination of tibial nerve and GAP-43 mRNA expression of sciatic nerve related spinal cord and ganglion were observed in 10%,20%,30%,40% lengthening, and at 2,4,8 weeks phases after 40% limb lengthening in 80 rabbits． Results With the increase of elongation, severer and more obvious nerve damage and stronger expression of GAP-43 mRNA happened． However, nerve regeneration occurred synchronously and the changes recovered gradually within 8 weeks． Conchusion Dsmage of the peripheral nerves is common during limb lengthining． But, it is temporary and recoverable in case the lengthening rate is < 1 mm/d．
