The potential targeted therapeutic drugs for melanoma
10.3760/cma.j.cn114453-20220311-00063
- VernacularTitle:黑色素瘤靶点及其靶向治疗药物
- Author:
Yu ZHU
1
;
Chuanyuan WEI
;
Jianying GU
Author Information
1. 复旦大学附属中山医院整形外科，上海 200032
- Keywords:
Melanoma;
Target therapy;
Drug target;
Clinical trial
- From:
Chinese Journal of Plastic Surgery
2023;39(6):666-672
- CountryChina
- Language:Chinese
-
Abstract:
Melanoma is a common and highly malignant tumor with rapid development, poor prognosis and high mortality in the field of plastic surgery. The incidence rate around the world is increasing year by year and the mortality rate ranks first among skin and soft tissue tumors. The rapid development of targeted and immunotherapeutic drugs has greatly improved the prognosis of patients with advanced melanoma. Currently, the improvement of curative effect brought by monotherapy with mainstream targeted drugs is still limited, and the overall remission rate is about 20%. A large number of clinical trials of non first-line and potential targeted drugs have been carried out, showing the value of these drugs and potential targets to clinicians. This article mainly reviews the potential targets and clinical trials of melanoma, in order to help clinicians better understand the prospect of targeted treatments of the disease and find more effective therapeutic drugs.
