Advances in the application of intragastric flora in the diagnosis and treatment of gastric cancer
10.3760/cma.j.cn441530-20231229-00233-1
- VernacularTitle:胃内菌群在胃癌的诊断与治疗中的应用进展
- Author:
Lei SUN
1
;
Xiangyun ZHENG
;
Guoning QIN
;
Yanmao ZHU
;
Lingqi KONG
;
Huanhu ZHANG
Author Information
1. 滨州医学院第二临床医学院，烟台 264003
- Keywords:
Stomach neoplasms;
Gastric flora;
Biological markers;
Chemotherapy;
Immunotherapy
- From:
Chinese Journal of Gastrointestinal Surgery
2024;27(7):756-763
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer is one of the major causes of cancer-related deaths worldwide, and infection with Helicobacter pylori and EBV, smoking and a salt-heavy diet have been shown to be risk factors for the development of gastric cancer. Currently, numerous research has demonstrated that differences in the structure of the gastric flora can be exploited to distinguish the different stages of gastric mucosal lesions and to predict the progression of gastric cancer. Therefore, a new biomarker is presented for the diagnosis of gastric cancer based on the structural differences of the gastric flora. Gastric flora has also potential in the treatment of gastric cancer. The application of non-H. pylori flora to modulate immune cells may increase the sensitivity of tumour cells for chemotherapy, improve the efficacy of immune checkpoint inhibitors and significantly prolong the survival of patients. This review of advances in the application of gastric flora in the diagnosis and treatment of gastric cancer is aimed at providing a reference and basis for future research in this field.
