Intraperitoneal chemotherapy for colorectal cancer peritoneal metastasis
10.3760/cma.j.cn441530-20230522-00177
- VernacularTitle:腹腔内化疗在结直肠癌腹膜转移中的应用
- Author:
Junwen YE
1
;
Huabin HU
;
Rui LUO
;
Huaiming WANG
;
Rongkang HUANG
;
Lili CHU
;
Hui WANG
Author Information
1. 中山大学附属第六医院普通外科（结直肠外科）广东省结直肠盆底疾病研究重点实验室 广州市黄埔区中六生物医学创新研究院 广东省生物医用材料转化与评估工程技术中心，广州 510655
- Keywords:
Intraperitoneal chemotherapy;
Colorectal neoplasms;
Peritoneal metastasis
- From:
Chinese Journal of Gastrointestinal Surgery
2024;27(6):646-652
- CountryChina
- Language:Chinese
-
Abstract:
Peritoneal metastasis is one of the common site of colorectal cancer metastasis and associated with a poor prognosis. The core strategy for colorectal cancer peritoneal metastasis primarily revolves around a comprehensive treatment approach with cytoreductive surgery and systemic chemotherapy as the mainstay, supplemented by intraperitoneal chemotherapy. As an important supplement to treatment, intraperitoneal chemotherapy has broad application prospects. The main modalities are hyperthermic intraperitoneal chemotherapy (HIPEC), neoadjuvant intraperitoneal and systemic chemotherapy (NIPS), early postoperative intraperitoneal chemotherapy (EPIC), sequential postoperative intraperitoneal chemotherapy (SPIC), normothermic intraperitoneal chemotherapy (NIPEC) and pressurized intraperitoneal aerosol chemotherapy (PIPAC). To promote the standardized application of intraperitoneal chemotherapy, further research on the mechanisms underlying peritoneal metastasis of colorectal cancer, selection of effective intraperitoneal chemotherapy agents, determination of optimal timing and administration protocols, exploration of the feasibility of sequential intraperitoneal chemotherapy and conduction of valuable basic and clinical research are currently needed. This paper will review the development and origins of intraperitoneal chemotherapy, treatment modalities, as well as the current application status and prospects of various treatment approaches in the context of peritoneal metastasis of colorectal cancer.
