Research progress in macrophages regulation on skin wound healing
10.3760/cma.j.cn114453-20210307-00105
- VernacularTitle:巨噬细胞对皮肤创面愈合的调控机制研究进展
- Author:
Ruoxuan ZHANG
1
;
Hongsen BI
Author Information
1. 北京大学第三医院成形外科，北京 100191
- Keywords:
Macrophages;
Diabetes mellitus;
Skin wound healing;
Polarization;
Epigenetic modification
- From:
Chinese Journal of Plastic Surgery
2023;39(2):231-236
- CountryChina
- Language:Chinese
-
Abstract:
Macrophages are important cell types involved in skin wound healing. In this article, recent advances in macrophage-mediated regulation of skin wound healing and the abnormal polarization of macrophages in diabetic refractory wounds are reviewed. Studies have shown that macrophages in skin wounds can be categorized into two types, M1 and M2. These two types exhibit different functions, including anti-inflammatory effects, angiogenesis promotion, fibroblast promotion and tissue shaping. The dysfunctions of macrophages, cytokine secretion and epigenetic modifications in diabetes mellitus can lead to abnormal polarization of macrophages. Targeting the regulation of macrophage polarization may be an effective approach to addressing skin refractory wounds.
