Regarding the selection of individualized therapy after neoadjuvant therapy for gastrointestinal tumors
10.3760/cma.j.cn441530-20240227-00076
- VernacularTitle:重视胃肠道肿瘤新辅助治疗后的个体化治疗选择
- Author:
Jianning ZHAI
1
;
Xiaokang LEI
;
Aiwen WU
Author Information
1. 北京大学肿瘤医院暨北京市肿瘤防治研究所 胃肠肿瘤中心三病区 恶性肿瘤发病机制及转化研究教育部重点实验室，北京 100142
- Keywords:
Gastrointestinal tumors;
Neoadjuvant therapy;
Organ preservation;
Watch and wait strategy
- From:
Chinese Journal of Gastrointestinal Surgery
2024;27(4):338-347
- CountryChina
- Language:Chinese
-
Abstract:
Gastrointestinal tumors have been widely concerned because of increasing morbidity and mortality. In the process of exploring the therapeutic patterns of gastrointestinal tumors, patients treated with neoadjuvant therapies have good effect of tumor regression and favorable prognosis. Thus, neoadjuvant therapy strategies are recommended by major guidelines of gastrointestinal tumors in the world. Meanwhile, they have a great impact on the traditional methods of surgery, the influence mainly involves the reduction of the surgical margin and the scope of lymph node dissection in gastric cancer, while involves performing organ preservation and watch & wait in selective patients with colorectal cancer. These effects and changes were based on effective control of local recurrence by neoadjuvant therapies, and the advantages of neoadjuvant therapy in terms of tumor regression and survival supported by many studies. It is also based on the patient's desire for organ preservation and non-surgical treatment. Meanwhile, application of neoadjuvant therapy strategies increase surgical difficulty and postoperative complications, but the overall impact on patient prognosis is weak. Therefore, the selection of an appropriate treatment model after neoadjuvant therapy requires an effective overall post-treatment evaluation. In particular, it is necessary to pay attention to the evaluation of imaging, endoscopy, etc., while effectively performing monitoring and follow-up, and finally establishing an appropriate salvage treatment. This article will review the status and problems of individualized treatment after neoadjuvant therapy of gastrointestinal tumor.
