Research progress on the prospect and mechanism for the role of polypeptides in the treatment of keloid
10.3760/cma.j.cn114453-20210627-00273
- VernacularTitle:多肽类物质治疗瘢痕疙瘩的作用及机制研究进展
- Author:
Yining ZHANG
1
;
Jijun ZOU
Author Information
1. 南京医科大学附属儿童医院烧伤整形科，南京 210008
- Keywords:
Keloid;
Polypeptide;
Fibroblast;
Collagen
- From:
Chinese Journal of Plastic Surgery
2022;38(10):1176-1180
- CountryChina
- Language:Chinese
-
Abstract:
Keloid is a type of skin fibroproliferative disease, characterized by excessive deposition of collagen in the extracellular matrix. There are many therapies for treating keloids now. However, the outcome of keloids treatment is still unsatisfied due to high recurrence rate. In recent years, polypeptides have shown great potential for preventing and treating keloid. These polypeptides are derived from cytokines, hormones and in vivo protehydrolysis. Polypeptides may inhibit the activation of fibroblasts, reduce the deposition of collagen and other extracellular matrix through multiple mechanisms. The article reviews current research progress on the roles of polypeptides and underlying mechanisms in keloid and provides reference for relevant research.
