Bone/cartilage organoid technology transforming clinical diagnosis and treatment strategies
10.12025/j.issn.1008-6358.2024.20240493
- VernacularTitle:骨/软骨类器官技术变革骨/软骨疾病临床诊疗策略
- Author:
Zuhao LI
1
,
2
;
Xiao CHEN
;
Jiacan SU
Author Information
1. 上海交通大学医学院附属新华医院骨科,上海 200092
2. 上海大学转化医学研究院,上海 200444
- Keywords:
bone organoid;
cartilage organoid;
construction strategy;
development stage;
clinical diagnosis and treatment
- From:
Chinese Journal of Clinical Medicine
2024;31(3):335-342
- CountryChina
- Language:Chinese
-
Abstract:
The diagnosis and treatment of motor system diseases are faced with some difficulties,such as unclear mechanism,low diagnostic efficiency,difficult model construction,slow drug development,and hard to bionic repair.Bone/cartilage organoids are a kind of tissue that can simulate the structure and function of bone/cartilage tissue by three-dimensional cultured cells in vitro.It provides a disruptive tool for research on bone/cartilage diseases and greatly revolutionize clinical diagnosis and treatment strategies in orthopedics.This paper systematically introduces the strategies and current research status of constructing bone/cartilage organoids to address the diagnostic and therapeutic dilemmas of bone/cartilage diseases.It proposes cutting-edge advancements that revolutionize clinical diagnosis and treatment strategies while summarizing the three stages of development from basic organoids,structured organoids to functionalized organoids.
