Research progress of tumor necrosis factor-α in hepatocellular carcinoma

VernacularTitle:肿瘤坏死因子α在肝细胞癌中的研究进展
Author: Yong HU ¹ ; Yixing CHEN ; Shisuo DU ; Zhaochong ZENG
Author Information

1. 复旦大学附属中山医院放疗科,上海 200032
Keywords: tumor necrosis factor-α; hepatocellular carcinoma; radiotherapy; prognosis
From: Chinese Journal of Clinical Medicine 2024;31(2):257-261
CountryChina
Language:Chinese
Abstract: Tumor necrosis factor-α(TNF-α)is a multifunctional inflammatory cytokine that has a bidirectional regulatory role in the occurrence and development of tumors.TNF-α participates in various regulatory pathways for the occurrence and development of hepatocellular carcinoma(HCC),but the mechanisms are not fully clear.Vascular endothelial growth factor(VEGF)and nuclear factor kappa B(NF-κB)signal pathways are considered as important roles in the occurrence and development of HCC.Peripheral blood TNF-α concentration and tumor tissue TNF-α concentration have shown good predictive values for the prognosis of HCC patients after receiving some treatments.The prognostic predictive value of TNF-α for HCC patients receiving precise radiotherapy needs to be further clarified.